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KMID : 0378019910340020117
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New Medical Journal
1991 Volume.34 No. 2 p.117 ~ p.123
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Clinical Evaluation of Sodium Hyaluronate (ARTZ^(®)) on Osteoarthritis of the Knee
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Abstract
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The aim of symptomatic treatment , either with nonsteroidal anti-inflammatory drugs or by physiotherapy, is inprinciple to return the decompensated and activated osteoarthrosis to alatent phase. Hyaluronic acid is one of the class of aminosugar containing polysaccharides known as the glycoaminoglycans. One of the most important biological functions of this molecule is to retain water in the matrix. Hyaluronic acid in the matrix has been demonstrated to be important to tissue functions such as tissue hydration, lubrication, soluye transport, cell migration, cell function and differentiation, ARTZ® is a sterile, non-pyrogenic, viscoelastic solution for injection. It contains sodium hyaluronate in physiological sodium chloride-phosphate buffer. The main clinical effects of ARTZ® are the prevention of the degeneration of articulate cartilage, normalization of synovial fluid, relief of pain and improvement of joint lubrication. A clinical studies have shown ARTZ to be effective and well-tolerated in the management of degenerative osteoarthritis of the knee. The efficacy and safety of ARTZ was evaluated during 8 months from March 1990 to October 1990. The results obtained were as follows:
1. The clinical efficacy of ARTZ was “marked improved: in 8 patients (27%), “moderately improved” in 14 patients (47%), “slightly improved” in 3 patients and “unchanged” in 3 patients (10%)
2. There was much improvement in global assessment, pain on movement and stiffness in Kellgren’s radiographic stage I, II than stage III. 3. The side effects were transient pain and localized severe pain after injection, in 6 patients (20%). But all of the symptoms were disappeared after 24 hours.
4. There was no significant difference between pre and post treatment laboratory values. In conclusion, ARTZ promotes the relief of pain, improvements of the joint lubrication in osteoarthritis. And it appears to be a safe and effective therapeutic agent in moderate osteoarthritis of the knee.
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KEYWORD
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